Welcome to ProMOL.

In recent years, structural genomics initiatives have generated a large number of protein structures. However, determining the function of these proteins through traditional experimental procedures can be a slow process. This disparity has been the motivation behind the creation of computational tools to predict function from structural homology. ProMOL is a plugin for the molecular visualization program, PyMOL, which uses catalytic site homology to predict the function of proteins with no known function.

                                ProMOL's Motif Finder

   Alignment of the query protein 1rbn (red) with motif protein 5rsa (white).


ProMOL includes the ability to:

  • make and store motif templates in a growing library of hundreds of existing motif templates

  • view optimal alignment between a motif template and a query structure

  • calculate the RMSD and Levenshtein distance between the query protein and its motif hits

  • request alignment with subsets of the motifs by template source and/or Enzyme Commission number

  • characterize a structure of unknown function via in silico methods

The ProMol project is sponsored by grants NSF-DUE 0402408, NIGMS 1R15GM078077, NIGMS 2R15GM078077-02, NIGMS 3R15GM078077-02S1, and NSF 1503811 and in part by Rochester Institute of Technology and Dowling College.

ProMOL is a collaborative effort between Dr. Paul Craig, Dr. Herbert Bernstein and Dr. Jeff Mills at Rochester Institute of Technology. free hit counters