Welcome to ProMOL.In recent years, structural genomics initiatives have generated a large number of protein structures. However, determining the function of these proteins through traditional experimental procedures can be a slow process. This disparity has been the motivation behind the creation of computational tools to predict function from structural homology. ProMOL is a plugin for the molecular visualization program, PyMOL, which uses catalytic site homology to predict the function of proteins with no known function.
ProMOL's Motif Finder
Alignment of the query protein 1rbn (red) with motif protein 5rsa (white).
ProMOL includes the ability to:
The ProMol project is sponsored by grants NSF-DUE 0402408, NIGMS 1R15GM078077, NIGMS 2R15GM078077-02, and NIGMS 3R15GM078077-02S1 and in part by Rochester Institute of Technology and Dowling College.
ProMOL is a collaborative effort between Dr. Paul Craig's group at Rochester Institute of Technology and Dr. Herbert Bernstein's group at Dowling College.