In recent years, structural genomics initiatives have generated a large number of protein structures. However, determining the function of these proteins through traditional experimental procedures can be a slow process. This disparity has been the motivation behind the creation of computational tools to predict function from structural homology. ProMOL is a plugin for the molecular visualization program, PyMOL, which uses catalytic site homology to predict the function of proteins with no known function.
ProMOL's Motif Finder
Alignment of the query protein 1rbn (red) with motif protein 5rsa (white).
ProMOL includes the ability:
ProMOL is a collaborative effort between Dr. Paul Craig's group at Rochester Institute of Technology and Dr. Herbert Bernstein's group at Dowling College.